Medications that can be used for the treatment of malaria in pregnancy include chloroquine, quinine, atovaquone-proguanil, clindamycin, mefloquine (avoid in first trimester), sulfadoxine-pyrimethamine (avoid in first trimester) and the artemisinins (see below).
Which malaria drug is safe for a pregnant woman?
The antimalarials that can be used in pregnancy include (1) chloroquine, (2) amodiaquine, (3) quinine, (4) azithromycin, (5) sulfadoxine-pyrimethamine, (6) mefloquine, (7) dapsone-chlorproguanil, (8) artemisinin derivatives, (9) atovaquone-proguanil and (10) lumefantrine.
Is it safe to take malaria tablets while pregnant?
The antimalarial drug usually recommended for pregnant women is mefloquine. It appears to be safe to take in pregnancy. However, if you are in in the first 12 weeks of pregnancy or if you are breastfeeding, you should talk to a specialist with experience in managing malaria before taking any antimalarial drugs.
Can malaria drug affect early pregnancy?
The treatment of all falciparum malaria is artesunate-based combination therapy (ACT), however, it is not recommend during the first pregnancy trimester as it has been proven toxic in animal studies, potentially causing birth defects or miscarriage.
Can anti malaria drugs cause miscarriage?
Malaria can increase the risk of miscarriage in early pregnancy, but treatment with antimalarial drugs appears safe and does not increase miscarriage risk, according to a large retrospective study in Thailand (McGready R et al.
What are the signs of malaria in pregnancy?
If a baby is infected with malaria, the baby might develop symptoms of fever, irritability, feeding problems, breathing problems, sluggishness, paleness, anemia, an enlarged liver and spleen, jaundice, and diarrhea in the weeks after birth.
When can I treat malaria in pregnancy?
Uncomplicated malaria in pregnancy
Currently, quinine and clindamycin is the recommended treatment for women in the first trimester of pregnancy31.
Can a three month pregnant woman take malaria drugs?
This is because: antimalarials can be harmful to developing babies if they’re taken at the time of conception or for up to 3 months afterwards. pregnant women have an increased risk of developing severe malaria and a higher risk of dying from it compared with non-pregnant women.
Can Coartem cause miscarriage?
Coartem may increase your risk for loss of pregnancy. Fetal defects have been reported when artemisinins are administered to animals.
Can artemether affect pregnancy?
However, limited availability of quinine and increasing resistance to mefloquine restrict these options. Strong evidence now demonstrates that artemether-lumefantrine (AL) (Coartem) is effective and safe in the treatment of malaria in pregnancy.
What weeks are the highest risk for miscarriage?
The first trimester is associated with the highest risk for miscarriage. Most miscarriages occur in the first trimester before the 12th week of pregnancy. A miscarriage in the second trimester (between 13 and 19 weeks) happens in 1% to 5% of pregnancies.
Is Lonart safe in first trimester?
Can I take Lonart Ds Tab during pregnancy? A: This medicine has known to cause or suspected to cause harmful effects on the developing fetus, thus not recommended for use in pregnant women.
What happens if a pregnant woman gets malaria?
Malaria infection during pregnancy can have adverse effects on both mother and fetus, including maternal anemia, fetal loss, premature delivery, intrauterine growth retardation, and delivery of low birth-weight infants (<2500 g or <5.5 pounds), a risk factor for death.