One recent meta-analysis of eight studies suggested that exposure to ondansetron in the first trimester could cause a very small increase in the risk of heart defects and orofacial malformations like cleft palate in babies.
Will Zofran hurt my unborn baby?
If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.
Is Zofran really linked to birth defects?
Zofran was found to double the risk of heart defects including atrial and ventricular septal (“hole in the heart”) defects and increased the overall risk of birth defects by 30% in one study. Another study found Zofran was linked with a 237% risk of cleft palate defects.
Can I take Zofran in first trimester?
A new study from Brigham and Women’s Hospital finds that pregnant women taking the common anti-nausea medication ondansetron during the first trimester have no increased risk of cardiac malformations and only a slight increased risk of oral clefts.
Is Zofran contraindicated in pregnancy?
It has been used off-label to treat nausea and vomiting in pregnancy. Based on recent studies regarding the association between Zofran use in early pregnancy and congenital cardiac malformations and oral clefts (cleft lip and palate), the FDA has cautioned against its use in pregnancy.
Is it OK to take Zofran everyday while pregnant?
Taking Zofran while pregnant is low risk, and it has been prescribed for years for pregnancy nausea. That said, Zofran for pregnancy nausea is an off-label use, and there may be better options.
Is it OK to take nausea medicine while pregnant?
In fact, the FDA has approved a prescription medication for use during pregnancy that is a combination of Vitamin B6 and Unisom. It is called Diclegis. This is the only FDA approved medication for treating nausea and vomiting during pregnancy.
Is Zofran safe in second trimester?
A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.
How often does Zofran cause birth defects?
Every pregnancy starts out with a 3-5% chance of having a birth defect. This is called the background risk. Most studies have found no increased chance for birth defects among thousands of people who used ondansetron in the first trimester of pregnancy.
Can Zofran cause miscarriage?
Currently, no scientific evidence has linked the anti-nausea drug Zofran, frequently prescribed “off-label” for morning sickness, to an increased risk of miscarriage.
Is metoclopramide safe in first trimester?
In summary, this large cohort study shows that exposure to metoclopramide in the first trimester of pregnancy is not associated with significantly increased risks of congenital malformations, low birth weight, or perinatal death.
How long does it take for Zofran to work for morning sickness?
Zofran (ondansetron) begins to work within about 30 minutes. It reaches peak blood concentrations in about 2 hours. Zofran’s effects can last 8 to 12 hours. The Zofran dosage varies depending on the severity and cause of the nausea and vomiting.
How quickly does Zofran work?
Ondansetron for nausea and vomiting sickness. Ondansetron is an anti-sickness medicine. It will start to work within 1-2 hours.
What is the best anti nausea medication for pregnancy?
If your nausea and vomiting is so severe that the first- and second-line treatments have not suppressed symptoms to an adequate level then your doctor may prescribe Ondansetron (known also as Zofran).
Is ondansetron safe in pregnancy NHS?
The Royal College of Obstetricians and Gynaecologists recommends the use of ondansetron should be limited to patients who are not adequately managed on the first- and second-line anti-emetics above, and preferably used after the first trimester of pregnancy.